| 灵芝三萜单体细胞保护与自噬诱导活性比较 |
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| 引用本文： | 许晓燕,罗霞,邱欣玉,魏巍,江南,郑林用,余梦瑶. 灵芝三萜单体细胞保护与自噬诱导活性比较[J]. 中国食用菌, 2013, 0(6): 32-35 |
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| 作者姓名： | 许晓燕 罗霞 邱欣玉 魏巍 江南 郑林用 余梦瑶 |
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| 作者单位： | [1]四川省中医药科学院,四川成都610041 [2]四川大学生命科学学院,四川成都610064 [3]四川省农业科学院,四川成都610066 |
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| 基金项目： | 四川省科技l亍科技支撑计划“治疗老年痴呆症的中药五类新药候选药物研究”（2011SZ0061）;四川省中医药管理局青年中医药课题“筛选治疗神经退行性疾病中药有效成分（部位）的高通量自噬检测细胞模型的构建”（2012-E-053）;四川省中医药科学院基本科研业务专项“基于自噬陕速检测细胞模型的中药治疗神经退行性疾病有效成分（部位）高通量筛选方法的构建”（A-2011N-10）. |
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| 摘 要： | 比较不同灵芝三萜单体对PCI2细胞保护和自噬诱导活性的差异。结果表明，灵芝酸A、B、C、C2、DM、K对H2O2诱导的细胞损伤最大保护率分别为32．83％、12．63％、53．03％、30．30％、2．53％和25．25％；对Aβ25-35诱导的细胞损伤最大保护率分剐为6．74％、29．02％、23．81％、25．07％、10．15％和5．12％；自噬诱导最大阳性率分别达到22．33％、32．67％、35．50％、28．33％、11．83％和29．50％。不同灵芝三萜单体的活性也有明显的差异，且各单体在不同活性方面均未表现出一致的强弱关系。
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| 关 键 词： | 灵芝 三萜 阿尔茨海默症 神经保护 |
The Different Effects of Ganoderma Triperpenoids on Cytoprotection and Autophagy Induction in PC12 Cells |
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| XU Xiao-yan,LUO Xia,QIU Xin-yu,WEI Wei,JIANG Nan,ZHENG Lin-yong,YU Meng-yao. The Different Effects of Ganoderma Triperpenoids on Cytoprotection and Autophagy Induction in PC12 Cells[J]. Edible Fungi of China, 2013, 0(6): 32-35 |
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| Authors: | XU Xiao-yan LUO Xia QIU Xin-yu WEI Wei JIANG Nan ZHENG Lin-yong YU Meng-yao |
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| Affiliation: | 1. Sichuan Institute of Chinese Materia Medica, Chengdu Sichuan 610041 ; 2. College of Life Science, Sichuan University, Chengdu Sichuan 610041; 3. Sichuan Academy of Agricultural Sciences, Chengdu Sichuan 610041 ) |
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| Abstract: | The different effects of C,.anoderrna triperpenoids on cytoprotection and autophag＇y induction in PC12 cells were studied. The results showed that the maximum protection rates of Ganoderie acid A, B, C, C2, DM, K on H2O2 induced toxicity were 32. 83%, 12. 63%, 53.03%, 30. 30%, 2. 53% and 25.25%, respectively. The maximum protection rates on Aβ25-35 induced toxicity were 6. 74%, 29. 02%, 23.81%, 25.07%, 10. 15% and 5.12%, respectively. The maximum autophagy induction rates were 22. 33%, 32. 67%, 35.50%, 281 33%, 11.83% and 29. 50%, respectively. There was a very significant difference in C, anoderma triperpenoids on eytoprotection and autophagy induction, and the rankings of a certain triperpenoid were varied in different activity tests. |
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| Keywords: | Gartoderma Triperpenoids Alzheimer＇ s Disease Neuroproteetion Autophagy |
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