扇贝边多肽提取物对高脂血症大鼠血脂以及脂质氧化的影响

采用高脂饲料制造大鼠高脂血症模型,研究扇贝边多肽提取物对高脂模型大鼠血脂以及肝脏脂质过氧化的影响.结果表明,与高脂模型组大鼠比较,低、中、高剂量组扇贝边多肽提取物能不同程度地降低大鼠血液中的TC、TG、LDL-C及肝脏的MDA水平,增加血液中HDL-C含量,并增强肝脏抗超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-pX)的活性,其中低剂量组各指标与高脂模型组比较无统计学意义,而中、高剂量组各指标接近,且与高脂模型组比较,均达到统计学意义.说明一定剂量的扇贝边多肽提取物能降低大鼠血脂,增强肝脏的抗氧化能力,具有潜在的肝脏保护功能.

Effects of the scallop skirt peptide extract in regulating blood lipid and anti-oxidation of rats with hyperlipidemia

Rats with hyperlipidemia were made by feeding high fat forage in order to evaluate the effects of the scallop skirt peptide extract in regulating blood lipid and anti-oxidation.Results showed that compared with the model control group,media and high dosage group of scallop skirt peptide extract could significantly reduce the TC,TG,LDL-C levels of serum and the MDA levels of liver,while the activities of antioxidative enzymes including SOD and GSH-pX also increased significantly,although the effects of both the media and high dosage groups were similar.The groups with low dosage of scallop skirt peptide extract showed no significant changes on the above indexes compared with the model of control group.This study indicated scallop skirt peptide extract with certain dosage had the effects of lipid adjustment and anti-hyperoxidization,and could also strengthen the antioxidative effect of liver thus to protect liver.