In vitro anti-uveal melanoma activity of phenolic compounds from the Egyptian medicinal plant Acacia nilotica |
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Authors: | Salem Manar M Davidorf Frederick H Abdel-Rahman Mohamed H |
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Affiliation: | aDepartment of Pharmacognosy, Faculty of Pharmacy, Tanta University, Egypt;bDepartment of Ophthalmology, The Ohio State University, Columbus, Ohio 43210, USA |
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Abstract: | Anti-uveal melanoma activity-guided fractionation of the MeOH extract of Acacia nilotica pods resulted in the isolation of the new compound gallocatechin 5-O-gallate (5) in addition to methyl gallate (1), gallic acid (2), catechin (3), catechin 5-O-gallate (4), 1-O-galloyl-β-D-glucose (6), 1,6-di-O-galloyl-β-D-glucose (7) and digallic acid (8). The structures of the isolated compounds were elucidated on the basis of HRESIMS, NMR spectroscopy and CD data. In addition to uveal melanoma, the antiproliferative activities of the isolated compounds and the related compound epigallocatechin 3-O-gallate (EGCG) were evaluated against cutaneous melanoma, ovarian cancer, glioblastoma and normal retinal pigmented cells. |
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Keywords: | Acacia nilotica Fabaceae Catechins Polyphenolics Uveal melanoma |
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