Types of transdifferentiation of renal tubular epithelial cells and its role in kidney diseases |
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| Authors: | WANG Xuan YUAN Wei-jie |
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| Affiliation: | Division of Nephrology, the First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200080, China |
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| Abstract: | The normal shape and functions of renal tubular epithelial cells are very important for keeping renal function. Under pathological conditions, renal tubular epithelial cells transform to myofibroblast or immunocytes. The transdifferentiation of renal tubular epithelial cells acts in the progresses of many kidney diseases, such as diabetic nephropathy and lupus nephritis. In this review, we summarize the types of transdifferentiation of renal tubular epithelial cells and its roles in kidney diseases. |
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| Keywords: | Renal tubular epithelial cells Transdifferentiation Kidney diseases |
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