Risk factors of respiratory infections in patients with hematopoietic stem cell transplantation at early stage

AIM:To investigate the pathological status, hematopoietic reconstitution and risk factors of respiratory infections(RI) in the patients with hematopoietic stem cell(HSC) transplantation at early stage. METHODS:The retrospective and case-control study, single-factor and Logistic analysis were performed to analyze the clinical data of 168 patients with HSC transplantation. RESULTS:The incidence rate of RI was 72.6%, upper RI was 44.0%, and lower RI was 28.6%. The cases with RI attacked before hematopoietic reconstitution were 81.1%. The risk factors of RI analyzed by single factor were age, origin of HSC, pretreatment, non-genetic transplantation, non-complete matching of human leukocyte antigen(HLA), hemogram recovery time, and independent risk factors were age and non-genetic transplantation. The risk factors of upper RI were age, origin of HSC, non-genetic transplantation, non-complete matching of HLA, hemogram recovery time, and independent risk factors were age and non-genetic transplantation. The risk factors of lower RI were the origin of HSC, non-genetic transplantation, non-complete matching of HLA, history of fungal pneumonia and graft-versus-host disease(GVHD), and independent risk factors were non-complete matching of HLA and history of fungal pneumonia. CONCLUSION:Higher incidence rate of RI exists at early stage of HSC transplantation, and independent risk factors include age, non-genetic transplantation, non-complete matching of HLA and history of fungal pneumonia.