Role of P-selectin in intestinal tumorigenesis in ApcMin/+ mice |
| |
Authors: | GUO Si-mei QI Cui-ling YE Jie ZHOU Qin WANG Li-jing |
| |
Institution: | Institute of Vascular Biology, Guangdong Pharmaceutical College, Guangzhou 510006, China |
| |
Abstract: | AIM: To investigate the role of P-selectin in intestinal tumorigenesis in ApcMin/+ mice (C57BL/6J-ApcMin/J). METHODS: Female P-selectin knockout mice (B6.129S7-Selptm1Bay /J, that was P-selectin -/-) were mated with male ApcMin/+ mice. The offspring was genotyped for Min +/- and P-selectin null mutantions, which were ApcMin/+ P-selectin -/- mice. The tumor number and gross tumor volume in the small and large intestines of the ApcMin/+ P-selectin -/- mice and ApcMin/+ mice were determined. RESULTS: P-selectin deficiency in ApcMin/+ mice resulted in significant decreases in the tumor number and gross tumor volume in the small intestine and total intestine. CONCLUSION: Deletion of P-selectin significantly inhibits the tumorigenesis in mouse intestines. In addition, the results also suggest that P-selectin may be a marker for colon cancer. |
| |
Keywords: | P-selectin Genetically engineered mice Intestinal neoplasms |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|