滔罗定对大肠杆菌和沙门氏菌混合感染鸡的药效学试验

摘要：研究了滔罗定的体外抑菌效果及对人工混合感染雏鸡大肠杆菌和沙门氏菌病的治疗效果。采用试管两倍稀释法测定滔罗定对大肠杆菌和沙门氏菌的最小抑菌浓度。选择180只4日龄罗曼雏鸡随机分为健康组（Ⅰ），感染对照组（Ⅱ)，氟苯尼考治疗对照组（Ⅲ）和滔罗定高、中、低剂量组（Ⅳ、Ⅴ、Ⅵ）等6个不同处理组，进行人工致病治疗试验。试验结果：与感染对照组相比，滔罗定高、中剂量组的死亡率分别降低了20.0%、16.7%，治愈率分别提高了23.3%、16.6%，差异均极显著(P<0.01)；滔罗定高、中剂量组的有效率和治愈率均高于氟苯尼考组，但差异不显著(P>0.05)；滔罗定对大肠杆菌和沙门氏菌的最小抑菌浓度大于或等于256 μg/mL。结果表明，滔罗定对人工混合感染雏鸡大肠杆菌和沙门氏菌病具有一定的治疗效果。

Efficacy of Taurolidine against mixed infection with Escherichia coli and Salmonella in chickens

Abstract: The antibacterial activies and efficacy of Taurolidine against mixed infection with Escherichia coli and Salmonella in chickens was carried out. By means of 2-fold diluent method, the MIC of antibacterial activies of Taurolidine were obtained. One hundred eighty of four-day old chickens were randomly devidedinto eight groups: I was uninfected and unmedicated control, II was infected and unmedicated control, III was Florfenicol treatment group, IV,V,VI were Taurolidine treatment groups with high, moderate and low dose, respectively. Compared with infected and unmedicated group, the died rate of high dose and moderate dose of Taurolidine group was reduced 20.0%,16.7%, respectively. The healing rate of high dose and moderate dose of Taurolidine group was increased 23.3% and 16.6%, respectively. The effectiveness and healing rate of high dose and moderate dose of Taurolidine was better than Florfenicol group. The MIC of antibacterial activies of Taurolidine against Escherichia coli and Salmonella was not lower than 256 μg/mL. The results showed that Taurolidine has certain efficacy against mixed infection with Escherichia coli and Salmonella.