| 病毒性腹泻-粘膜病病毒实验感染绵羊及其血清中和抗体的消长规律 |
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| 引用本文： | 徐彦勤,李佑民. 病毒性腹泻-粘膜病病毒实验感染绵羊及其血清中和抗体的消长规律[J]. 中国兽医学报, 1989, 0(3) |
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| 作者姓名： | 徐彦勤 李佑民 |
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| 作者单位： | 兽医大学传染病教研室(徐彦勤)，兽医大学传染病教研室(李佑民) |
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| 摘 要： | 将6只8月龄公绵羊随机分为2组,分别经肌肉注射和滴鼻两途径,每只羊给予BVD/MDV长春184毒株第14代肾细胞培养毒澄清液20mL。结果,两种途径感染羊皆出现牛粘膜病的类似症状,并产生明显的抗体反应,中和抗体消长规律因接种途径不同而有所差异。感染羊在接种后第2周产生抗体,10～15周抗体滴度达到高峰,在1:160以上至少能持续11～17周。肌注组抗体产生较早,升高较快,持续时间短,至第27周抗体降至1:20。滴鼻组抗体升高较缓慢,持续时间较长,至第27周抗体滴度仍在1:160以上。实验还证明,BVD/MDV长春184毒株及Oregon毒株均能在MDBK、BT及牛睾丸细胞上繁殖,并有明显的细胞病变。
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| 关 键 词： | BVD/MDV 实验感染 中和抗体消长规律 绵羊 |
Serum Neutralization Antibody Changes of Rams Experimentally Infected with Bovine Virus Diarrhea-Mucosal Disease Virus (BVD/MDV) |
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| Xu Yanqin et al. Serum Neutralization Antibody Changes of Rams Experimentally Infected with Bovine Virus Diarrhea-Mucosal Disease Virus (BVD/MDV)[J]. Chinese Journal of Veterinary Science, 1989, 0(3) |
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| Authors: | Xu Yanqin et al |
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| Affiliation: | Xu Yanqin et al. Department of Epizootiology,Veterinary College of PLA |
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| Abstract: | Six rams (eight-month old) of local breed were randomly divided into 2 groups and were infected with clarified fluid of14th passage of kidney cell culture of Changchun-184 strain ofBVD/MDV intramuscularly or intranasally. The inoculum was 20mL.All inoculated rams showed similar clinical signs of bovine virusdiarrhea-mucosal disease. Their serum neutralization antibodiesappeared from 1-2 weeks after infection and a peak titer reachedwithin 10-15 weeks. Titer levels of 1: 160 or more lasted at least11-17 weeks. Serum neutralization antibody in intramuscularly infectedrams could be detected earlier than those in intranasally infectedgroup. In the former group the titer increased slightly faster butlasted shorter as compared with later. |
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| Keywords: | BVD/MDV experimental infection serum neutralization antibody changes sheep |
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