Association between survivin promoter -31C/G polymorphism and genetic susceptibility to sporadic colorectal cancer |
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Authors: | HUANG Jun WANG Jian-ping WANG Lei LIU Huan-liang WEI Yi-sheng HUANG Mei-jin FU Xin-hui CHEN Jing CHEN Dian-ke |
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Institution: | 1.Department of Colorectal Surgery, The Sixth Affiliated Hospital, 2Gastrointestinal Institute, Sun Yat-sen University, Guangzhou 510655, China. E-mail: wjp@mail.sysu.edu.cn |
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Abstract: | AIM: To investigate the association between -31C/G polymorphism in the promoter of survivin gene and the susceptibility to sporadic colorectal cancer (CRC) in southern Chinese population. METHODS: survivin -31C/G genotypes were determined by PCR-RFLP in 711 healthy controls and 702 CRC cases. RESULTS: The number of CRC patients carrying with CC genotype was much higher than that of controls (36.5 % vs 26.2%,2 =17.89,P<0.01). Compared to CC genotypes, CG, GG genotypes and G allele carriers had a significantly decreased risk of CRC, with the decrease being 0.61-fold (95% confidence interval=0.46-0.80, P<0.01), 0.52-fold (95% confidence interval=0.38-0.71,P<0.01) and 0.58-fold (95% confidence interval=0.45-0.74, P<0.01), respectively. CONCLUSION: survivin gene -31C/G polymorphism is associated with sporadic CRC risk, the G variant genotype is the independent protective factors against sporadic CRC in southern Chinese population. |
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