Changes of coronary flow reserve and myocardial blood flow after coronary microembolization |
| |
| Authors: | MA Jian-ying QIAN Ju-ying GE Jun-bo QIU Zhen ZHANG Feng GE Lei LIU Xue-bo WANG Yuan-yuan SUN Ai-jun ZOU Yun-zeng |
| |
| Institution: | 1.Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Disease, Shanghai 200032, China;2.Department of Electronic Engineering, Fudan University, Shanhai 200433,China.E-mail:ge.junbo@zs-hospital.sh.cn;qian.ju-ying@zs-hospital.sh.cn |
| |
| Abstract: | AIM:To investigate the changes of coronary flow reserve (CFR) and myocardial blood flow (MBF) after coronary microembolization (CME).METHODS:The left anterior descending coronary artery of 12 pigs was embolized by injection of 42 μm microspheres with a total of 120 000.Study was divided as acute study (base, 2 h and 6 h) and chronic study (base and 1 week).CFR was measured using Doppler wire.Regional myocardial blood flow (MBF) was detected using colored microspheres.Serum endothelin-1(ET-1) was determined by ELISA.RESULTS:CFR decreased significantly after CME at acute phase (2.10±0.60 at baseline, 1.40±0.10 at 2 h and 1.10±0.10 at 6 h, 2 h and 6 h compared with base, P<0.01, respectively).At chronic phase, CFR was 2.03±0.43 at base and 1.58±0.22 at 1 week after CME.No changes were found for MBF at acute and chronic study.Serum ET-1 only elevated at 6 h after CME.CONCLUSION:CFR decreases with time at acute phase after CME and resumes 1 week later.Changes of CFR correlate with changes of endothelial function.Changes of CFR and MBF are mismatched after CME. |
| |
| Keywords: | |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|
