Association between platelet membrane glycoprotein IIb polymorphism and coronary heart disease in Han people

AIM: To investigate the genotype distributions of HPA-3 in Han people from Beijing and Hebei province, and to study the association of the platelet glycoprotein IIb polymorphism with coronary heart disease (CHD).METHODS: Two hundred and twelve patients with coronary heart disease and 106 healthy controls were enrolled in this case-control study. The number of occlusive coronary artery was performed in all subjects. The genotypes of HPA-3 were determined by TaqMan probe technology. RESULTS: In CHD patients (older than 45 years) carriers of HPA-3b were over- represented compared with healthy controls (P<0.05). The prevalence of HPA-3 genetic variants had no difference in CHD patients of different numbers of occlusive coronary artery. Results were statistically evaluated with Binary Logistic regression, which showed the HPA-3 polymorphism was associated with an increased risk for CHD(OR: 2.105).CONCLUSION: The HPA-3 polymorphism of GP IIb is the risk factor of CHD in Han people, especially in patients older than 45 years.