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Oxidative stress damage to mitochondria mediated the pathological processes in epilepsy
Authors:LIU Zhao-wei  ZHANG Tao  YANG Zhuo
Institution:Key Laboratory for Biological Active Material of Ministry of Education, 1College of Life Science,2College of Medicine, Nankai University, Tianjin 300071, China. E-mail: zhuoyang@nankai.edu.cn
Abstract:Recent studies show that epileptic seizures result in mass free radical production and induce oxidative damage because of relative deficiency in anti-oxygen system. Mitochondrium is crucial to sustaining energy metabolism, regulating cell death, synthesising neurotransmitter and oxidating fatty acid. Mitochondrium is not only the place for free radical production, but also the target of oxidative damage. Mitochondrial oxidative stress and resultant dysfunction enhance epileptic susceptibility. Seizure-induced free radical can influence energy metabolism, destroy DNA construction and induce apoptosis in neurontoxic consequences in epilepsy.
Keywords:Epilepsy  Oxidative stress  Mitochondria  Free radicals  
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