Autophagy and myocardial ischemia/reperfusion injury |
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Authors: | LIU You-bin YANG Shu-sen FAN Ying GAN Run-tao |
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Institution: | Department of Cardiology, The First Affiliated Hospital of Haerbin Medical University, ;Haerbin 150001, China. E-mail:aini2002yx@163.com |
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Abstract: | Autophagy is a lysosome-dependent degradative pathway which is characterized by cytoplasmic vacuolization. However, it is not just a simple degradative pathway. Research shows that autophagy is related to many diseases, such as neurodegenerative disease, malignant tumor, ageing, pathogenic microorganism infection, myocardial ischemia/reperfusion injury and so on. Autophagy exactly exists in myocardial ischemia/reperfusion injury, and it becomes a new research hotspot. This review will focus on the occurrence and development of autophagy and its role, signal transduction and research status in myocardial ischemia/reperfusion injury. |
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