Effects of Shan He Jian Fei Granule on the expression of leptin,adiponectin and resistin in obese rats induced by high-fat feeding |
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Authors: | SUN Sheng-yun HUANG Jin MENG Min-jie LU Jia-hai YANG Qin-he ZHANG Rong-hua ZHU Xiao-feng LIU Kang-li |
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Affiliation: | 1.Institute of Qi and Blood of Intergrative Medicine, Jinan University, Guangzhou 510630, China;2.School of Life Science and Biopharmacology, Guangdong Pharmaceutical University, Guangzhou 510006, China;3.School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. E-mail:gzssy@163.com |
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Abstract: | AIM: To study the effects of Shan He Jian Fei Granule (SHJFG), a Chinese medicine, on weight-reduction and fat-decrease in adiposity rats, and to observe the changes of leptin, adiponectin and resistin. METHODS: After the models were prepared successfully, the rats were randomly divided into four groups: normal group, low dosage, middle dosage, high dosage and obesity control group. After 8 weeks interference with SHJFG, the weight and the naso-anal length of each rat was measured and Lees index were calculated. The levels of TG, TC, LDL, HDL and leptin in serum were carefully determined. The gene expressions of adiponectin and resistin in adipose tissues of rats were determined by RT-PCR. RESULTS: Compared to high-fat diet group, the body weights, the Lees indexes, the weight of fat tissues and levels of TG, TC, LDL and leptin in SHJFG groups significantly decreased (P<0.05). Adiponectin mRNA expression in SHJFG group significantly increased (P<0.05), and the resistin mRNA expression also significantly increased. CONCLUSION: SHJFG significantly decreases the body weight and the serum levels of TG, TC and LDL in obese rats. The effects of SHJFG in raising the mRNA expressions of adiponectin and resistin in fat tissues may be one of the main role that results in lowering body weight in obese rats. |
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