Antitumor effect of heat-killed lactobacilli adhered to cervical carcinoma cells |
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| Authors: | WANG Hong-yan WU Xiao-yan ZHANG Xu-yan XING Yong-mei ZHOU Ya-bin JIA Ji-hui TIAN Yong-jie |
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| Institution: | 1.Department of Microbiology, 2Department of Gynaecology, Affiliated Hospital, Weifang Medical College, Weifang 261042, China;3.Teratology Laboratory of Ministry of Education, Shandong University School of Medicine, 4Department of Gynaecology, Shandong Shengli Hospital, Affiliated Hospital to Shandong University, Jinan 250012, China. E-mail: yjiet@tom.com |
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| Abstract: | AIM: To observe the immune property of cervical carcinoma and antitumour effect of heat-killed lactobacilli adhered to HeLa cells. METHODS: Flow cytometry was used to analyze the expression of immune molecules on HeLa cells after adhered with heat-killed lactobacilli. MTT was used to analyze the cytotoxity of lymphocytes on cervical carcinoma cells. RESULTS: Adherence of heat-killed lactobacilli to HeLa cells did not affect the expression of MHC-I molecules (P>0.05), but enhanced the expression of CD80, CD86 significantly (P<0.05) in HeLa cells. Adherence of heat-killed lactobacilli to HeLa cells also enhanced the cytotoxity of NK cells. Compared to control, the cytotoxity of CTL to HeLa carcinoma cells was significantly enhanced by the adherence of heat-killed lactobacilli to HeLa cells (P<0.05). CONCLUSION: Heat-killed lactobacilli strengthen the antitumor effect on HeLa cells. |
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