| 和厚朴酚的合成研究 |
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| 引用本文： | 刘之华,童志平.和厚朴酚的合成研究[J].安徽农业科学,2011,39(3):1357-1358. |
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| 作者姓名： | 刘之华 童志平 |
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| 作者单位： | 西南交通大学生命科学与工程学院,四川成都,610031 |
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| 摘 要： | 建立一种合成和厚朴酚的方法：以4-溴-苯甲醚与4-烯丙基苯甲醚为原料;4-溴-苯甲醚在2,5-二甲基苯基溴化镁、异丙基氯化镁、40℃条件下进行反应,然后加入烯丙溴,得到4-溴-2-烯丙基苯甲醚;4-烯丙基苯甲醚在一定条件下溴代生成2-溴-4-烯丙基苯甲醚;将4-溴-2-烯丙基苯甲醚制成相应的格氏试剂,在NiCl2（PPh3）2催化下与2-溴-4-烯丙基苯甲醚进行交叉偶联,得到和厚朴醇甲醚,水解和厚朴醇甲醚即得到和厚朴酚。
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| 关 键 词： | 和厚朴酚 合成 格氏试剂 |
Study on Synthesis of Honokiol |
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| Institution: | LIU Zhi-hua et al(Southwest Jiaotong University,School of Life Science and Engineering,Chengdu,Sichuan 610031) |
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| Abstract: | This article provides one way for the synthesis of honokiol: taking 4-Bromo Anisole and 4-allylanisole as raw materials,4-Bromo Anisole had chemical reaction under 40 ℃ in THF and isopropyl magnesium chloride.Then added with allyl-bromide,4-bromo-2-allyl anisole was obtained.Under certain conditions,4-allylanisole generated 2-bromo-4-allyl anisole.Formulating 4-bromo-2-allyl anisole to corresponding Grignard reagent so as to cross-coupling with 2-bromo-4-allyl anisole after been catalyzed by NiCl2(PPh3)2,Honokiol methyl ether was obtained thusly.After hydrolyzing Honokiol methyl ether,honokiol was generated. |
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| Keywords: | Honokiol Synthesis Grignard reagent |
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