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Immunofluorescence studies of renal basement membranes in dogs with spontaneous diabetes |
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| Authors: | K Jeraj J Basgen R M Hardy C A Osborne A F Michael |
| Abstract: | Renal tissue from 12 dogs with spontaneous diabetes and 16 control dogs were studied by light, immunofluorescence, and electron microscopies. Significant linear staining for immunoglobulin G and albumin were observed in the glomerular and tubular basement membranes of dogs with spontaneous diabetes--similar to that observed in human diabetes. On immunohistochemical grounds, it would appear that the dog with spontaneous diabetes is an appropriate model of diabetes in persons. |
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