Usefulness of the murine model to study the immune response against Histoplasma capsulatum infection |
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| Authors: | Jorge H Sahaza Armando Pérez-Torres Edgar Zenteno Maria Lucia Taylor |
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| Institution: | 1. Laboratorio de Inmunología de Hongos, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México, DF 04510, Mexico;2. Unidad de Micología Médica y Experimental, Corporación para Investigaciones Biológicas, Medellín, Colombia;3. Laboratorio de Filogenia del Sistema Inmune de Piel y Mucosas, Departamento de Biología Celular y Tisular, Facultad de Medicina, UNAM, México, DF 04510, Mexico;4. Laboratorio de Inmunología, Departamento de Bioquímica, Facultad de Medicina, UNAM, México, DF 04510, Mexico |
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| Abstract: | The present paper is an overview of the primary events that are associated with the histoplasmosis immune response in the murine model. Valuable data that have been recorded in the scientific literature have contributed to an improved understanding of the clinical course of this systemic mycosis, which is caused by the dimorphic fungus Histoplasma capsulatum. Data must be analyzed carefully, given that misinterpretation could be generated because most of the available information is based on experimental host–parasite interactions that used inappropriate proceedings, i.e., the non-natural route of infection with the parasitic and virulent fungal yeast-phase, which is not the usual infective phase of the etiological agent of this mycosis. |
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| Keywords: | Histoplasma capsulatum Histoplasmosis Murine model Innate immunity Adaptive response |
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