| 聚酮类化合物及其应用 |
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| 引用本文： | 冯健飞,周日成,郭兴庭,张扬. 聚酮类化合物及其应用[J]. 现代农业科技, 2011, 0(3): 24-26 |
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| 作者姓名： | 冯健飞 周日成 郭兴庭 张扬 |
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| 作者单位： | 南京农业大学生命科学学院;作物遗传与种质创新国家重点实验室; |
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| 摘 要： | 由微生物和植物产生的聚酮类化合物(PK)的数量庞大,是一大类结构多样化和生物活性多样性的天然产物,已经成为新药的重要来源。综述了3种类型聚酮类化合物生物合成基因簇的特点,即以模块形式存在的I型聚酮合酶、包含一套可重复使用结构域的Ⅱ型聚酮合酶以及不需要ACP参与,以植物中的查耳酮合酶为代表的Ⅲ型聚酮合酶。介绍了近年来组合生物合成技术的基本原理、聚酮合酶的基本作用机制以及合成途径的研究进展。
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| 关 键 词： | 聚酮类化合物 应用 组合生物合成 微生物药物 |
Polyketide and Its Application |
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| FENG Jian-fei,ZHOU Ri-cheng,GUO Xing-ting,ZHANG Yang. Polyketide and Its Application[J]. Modern Agricultural Sciences and Technology, 2011, 0(3): 24-26 |
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| Authors: | FENG Jian-fei ZHOU Ri-cheng GUO Xing-ting ZHANG Yang |
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| Affiliation: | FENG Jian-fei 1 ZHOU Ri-cheng 2 GUO Xing-ting 1 ZHANG Yang 1(1 Life Science College,Nanjing Agricultural University,Nanjing Jiangsu 210095,2 State Key Laboratory of Crop Genetics & Germplasm Enhancement) |
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| Abstract: | The polyketides from microorganisms and plant which are comprise of a large and structurally diverse family of bioactive natural products,are still indispensable for drug discovery.Three types of polyketide synthase were briefly introduced,including the modular(TypeⅠ)PKS,TypeⅡ polyketides,in the synthesis of which a set of discrete monofunctional proteins were repeatedly employed and Type Ⅲ PKSs(chalcone synthase-like protein)that does not require acyl-carrier proteins(ACPs).The status of combinatorial biosynthesis technology in microbial medicine researches including polyketides and the machineries of three types of polyketide synthase were also mentioned in this paper. |
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| Keywords: | polyketide application combinatorial biosynthesis microbial medicine |
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