Metabolism of the methoxychlor isostere,dianisylneopentane, in mouse,insects, and a model ecosystem |
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Authors: | Joel R Coats Robert L Metcalf Inder P Kapoor |
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Institution: | Department of Entomology, University of Illinois, Urbana, Illinois 61801 USA |
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Abstract: | Dianisylneopentane or 1,1-bis(p-methoxyphenyl)-2,2-dimethylpropane was metabolized largely by O-demethylation to form mono- and diphenol derivatives. Only a small percentage was degraded by α-hydroxylation and rearrangement. In the model ecosystem, dianisylneopentane reacted very similarly to methoxychlor, accumulating in fish to about the same extent and yielding a slightly higher ratio of polar to nonpolar metabolites. The neopentyl group proved to be approximately as stable in biological systems as the isosterically equivalent trichloromethyl group. |
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Keywords: | To whom correspondence should be addressed |
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