A comparison of DDT and its biodegradable analogues tested on ATPase enzymes in cockroach |
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Authors: | D. Desaiah L.K. Cutkomp R.B. Koch |
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Affiliation: | Department of Entomology, Fisheries and Wildlife, University of Minnesota, St. Paul, Minnesota 55101 USA |
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Abstract: | Analogues of DDT (ethoxymethyl and methoxymethio derivatives) compared with DDT for their inhibitory action on the ATPase system from tissues of the cockroach, Periplaneta americana show similar, but less inhibitory effects. The mitochondrial (oligomycin-sensitive) Mg2+ ATPase activity from coxal muscle preparations was more sensitive to DDT than the two analogues; whereas, the muscle and nerve cord homogenates showed about equal sensitivity to the biodegradable analogues. The mitochondrial Mg2+ ATPase from nerve cord preparation was more sensitive to the three compounds than the Na+K+ ATPase activity. The significance of these results in relation to recent reports on the effect of DDT on Na+K+ ATPase is discussed. |
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