Beneficial Effect of S-allylcysteine (SAC) on Blood Glucose and Pancreatic Antioxidant System in Streptozotocin Diabetic Rats |
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Authors: | Ganapathy Saravanan Ponnusamy Ponmurugan |
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Institution: | (1) Research and Development Centre, Bharathiyar University, Coimbatore, Tamilnadu, India, 641046;(2) PG and Research Department of Biochemistry, Centre for Biological Science, K.S.R. College of Arts and Science, Thokkavadi, Tiruchengode, Tamil Nadu, India, 637215;(3) Department of Biotechnology, K.S.R. College of Technology, Thokkavadi, Tiruchengode, Tamil Nadu, India, 637215 |
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Abstract: | The aim of the present study was to evaluate the possible protective effects of S-allyl cysteine (SAC) on the antioxidant
defense system of pancreas in streptozotocin(STZ) induced diabetes in rats. The levels of blood glucose and TBARS in plasma
and pancreas were estimated in control and experimental groups of rats. To assess the changes in the cellular antioxidant
defense system, the level of reduced glutathione in plasma and pancreas and activities of superoxide dismutase and catalase
were assayed in pancreatic tissue homogenate. The levels of glucose, TBARS and enzymatic antioxidants were altered in diabetic
rats. These alterations were reverted back to near control levels after the treatment of SAC. The antidiabetic and antioxidant
effect of SAC was compared with glyclazide, a well-known hypoglycemic drug. These findings suggest that SAC treatment exerts
a therapeutic protective nature in diabetes by decreasing oxidative stress. |
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