| VE缺乏对雏鸡脑组织的氧化状态及神经细胞凋亡的影响 |
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| 引用本文： | 李艳飞,石发庆,王振勇.VE缺乏对雏鸡脑组织的氧化状态及神经细胞凋亡的影响[J].中国兽医学报,2005,25(1):71-72. |
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| 作者姓名： | 李艳飞 石发庆 王振勇 |
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| 作者单位： | 东北农业大学,动物医学院,黑龙江,哈尔滨,150030 |
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| 基金项目： | 黑龙江省教育厅基金资助项目(10531016);黑龙江省青年基金资助项目(QC02C24) |
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| 摘 要： | 采用低VE和添加不饱和脂肪酸的日粮饲喂1日龄雏鸡，建立了VE缺乏实验动物模型。检测其脑组织(大脑和小脑)中丙二醛和活性氧的含量及神经细胞凋亡的数量，并进行了相关性分析。结果表明，VE缺乏雏鸡脑组织中的丙二醛和活性氧含量及神经细胞凋亡的数量显著高于健康对照组(P＜0．05)，细胞凋亡的数量与大、小脑组织中丙二醛和活性氧含量呈显著的相关性(相关系数分别为0．7502、0．8155和0．8170、0．6931)，说明VE缺乏雏鸡脑组织处于氧化应激状态，并可诱导脑神经细胞凋亡。
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| 关 键 词： | 脑组织 神经细胞凋亡 丙二醛 小脑 活性氧 缺乏 脑神经细胞 雏鸡 VE 数量 |
| 文章编号： | 1005-4545(2005)01-0071-02 |
| 修稿时间： | 2003年9月22日 |
Effects of VE Deficiency on Oxidant State and Neurocyte Apoptosis of the Brain Tissues of Chicken |
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| LI Yan-fei,SHI Fa-qing,WANG Zhen-yong.Effects of VE Deficiency on Oxidant State and Neurocyte Apoptosis of the Brain Tissues of Chicken[J].Chinese Journal of Veterinary Science,2005,25(1):71-72. |
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| Authors: | LI Yan-fei SHI Fa-qing WANG Zhen-yong |
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| Abstract: | The trial chicken model with the V_E deficiency was set up by using low content of V_E and supplying unsaturated fatty acid in the feed.The content of MDA and active oxygen and quantity of neurocyte apoptosis were measured in cerebrum and cerebellum of trial chicken and correlation analysis was carried out in this experiment.The results showed that the content of MDA and active oxygen and quantity of neurocyte apoptosis of the brain tissuses of chicken with V_E defficiency were significantly higher than those of control ones and there were significant correlation between the content of MDA and active oxygen and quantity of apoptosis of neurocyte.The results indicated that the brain tissues of chicken with the V_E deficiency were in the state of super oxidant stress,which induced apoptosis of neurocyte. |
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| Keywords: | chicken V_E deficiency brain tissues superoxidant state apoptosis of neurocyte |
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