| 复方三氮唑核苷注射液对大白鼠的亚慢性毒性试验 |
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| 引用本文： | 龚倩,贾冬舒,马红霞,陈威. 复方三氮唑核苷注射液对大白鼠的亚慢性毒性试验[J]. 吉林农业大学学报, 1999, 21(1): 74-76 |
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| 作者姓名： | 龚倩 贾冬舒 马红霞 陈威 |
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| 作者单位： | 吉林农业大学动物科学系,长春130118 |
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| 摘 要： | 将复方三氮唑核苷主射液按高，中，低剂量分别给大白鼠皮下注射，每天１次，连续注射３０ｄ，观察试验鼠的生理状态及活动情况测定增重及血液生理生化指标，并进行病理解剖及病理组织学检查。结果表明，复方三氮唑核苷注射液对大白鼠的生理活动血液生理生化指标均无不良影响；病理组织学检查，仅高剂量组有１０％大白鼠发生肾小管上皮细胞轻度颗粒变性，其它组各器官均未见异常。
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| 关 键 词： | 复方三氮唑核苷注射液 大白鼠 毒性试验 |
| 文章编号： | 1000-5684(1999)01-0074-03 |
| 修稿时间： | 1998－07－20 |
Subchronic Toxicity Test of Ribavirin Compound in Rat |
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| GONG Qian et al.. Subchronic Toxicity Test of Ribavirin Compound in Rat[J]. Journal of Jilin Agricultural University, 1999, 21(1): 74-76 |
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| Authors: | GONG Qian et al. |
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| Abstract: | rats randomly divided into 4 treatment groups. They were provided ribavirin compound 27.29 (LD 50 1/10), 13.64 (LD 50 1/20), 9.10 (LD 50 1/30)) and 0 mg/100g body weight by hypodermic injection one time a day, respectivily. The experimental period were 30 days . The research results showed that ribavirin compound has no poisonous effects in normal activities, physiological index and biochemical index in rats. |
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| Keywords: | ribavirin compound rat poisonous test |
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