Residues of dimetridazole in eggs after treatment of laying hens

Laying hens were dosed orally with dimetridazole (DMZ) (50 and 250 mg/kg) for 3 days or intramuscularly (50 mg/kg), also for 3 days, and the residues were determined by liquid chromatography in albumen and yolk. The sensitivity of the whole procedure was 2 ng/g. The drug was excreted preferentially into the yolk (about 57% of the total) and the elimination period lasted for 4–6 days after treatment.Abbreviations AUC area under the plasma concentration-time curve - depletion time the time needed for the DMZ concentration to fall below 0.01 g/g - elimination rate constant - Cl clearance - DMZ demetridazole