Morphological observation of canine natural killer cells mediated cytotoxicity. |
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| Authors: | Y Nariai Nakada K Nariai T Kosaka M Kuwabara Y Kiuchi |
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| Institution: | Laboratory Animal Facility, School of Medicine, Yokohama City University, Yokohama, Kanagawa, Japan. |
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| Abstract: | The cytotoxic effects of canine NK cells on CL-1 target cells were examined by scanning electron microscopy (SEM). NK cell mediated cytotoxicity on CL-1 target cells was detected by 51Cr release assay. SEM showed that a canine NK cell extended projections to the CL-1 target cell. Furthermore, the surface of CL-1 target cells changed a mesh-like structure. Therefore, the cytotoxic effects of canine NK cells on CL-1 target cells were morphologically demonstrated. |
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