Microsomal enzymes in lambs and adult sheep,and their possible relationship to alveld |
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| Authors: | A Flåøyen E G Jensen |
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| Institution: | (1) Department of Large Animal Clinical Sciences, Norwegian College of Veterinary Medicine, POB 8146 Dep., 0033 Oslo 1, Norway;(2) Department of Pharmacology and Toxicology, Norwegian College of Veterinary Medicine, POB 8146 Dep., 0033 Oslo 1, Norway |
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| Abstract: | The difference in susceptibility to alveld between lambs and adult sheep may be caused by differences in the microsomal enzyme activities in their livers. There was no difference in NADPH-cytochrome c reductase or 7-ethoxyresorufin-O-deethylase (EROD) activity between ewes, control lambs and phenobarbitone-dosed lambs 3 weeks after dosing ceased. However, aldrin epoxidase activity was at that time significantly highest in the phenobarbitone-dosed lambs and significantly lowest in the ewes. The liver cytosolic glutathione transferase activity was significantly highest in the ewes and significantly lowest in the control lambs at the same time. |
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| Keywords: | aldrin epoxidase 7-ethoxyresorufin-O-deethylase glutathione transferase liver NADPH-cytochrome c reductase Narthecium ossifragum phenobarbitone sheep |
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