奶牛脂肪肝的病理学研究进展

脂肪肝是许多奶牛泌乳早期主要的代谢性疾病,并常引起奶牛疾病的发生和繁殖力下降.严重的病例,泌乳量和能量摄入减少.因此,病理学研究可为脂肪肝的预防和治疗提供有利的理论基础,每年可节省数百万美元的损失.脂肪肝是由于肝脏摄取脂类的量超过肝脏氧化和吸收的量,脂肪动员高浓度的血浆非酯化脂肪酸引起的.过量的脂肪以甘油三酯的形式储存于肝脏,造成细胞完整性和功能降低,从而造成肝脏功能改变.文章从脂肪肝的基础病理、临床病理、免疫病理以及生殖病理方面,论述了脂肪肝的病理学研究进展.

Progress on Pathology of Fatty Liver in Dairy Caws

Fatty liver is a major metabolic disorder of many dairy cows in early lactation and is associated with decreased health status and reproductive performance. In severe cases, milk production and feed intake are decreased. Therefore, study on pathology of fatty liver could provid rationale for prevention or treatment of fatty liver and save millions of dollars yearly in treatment. Fatty liver develops when the hepatic uptake of lipids exceeds the oxidation and secretion of lipids by the liver, which usually is preceded by high concentrations of plasma NEFA mobilized from adipose tissue. Excess lipids are stored as triacylglycerol in the liver and are associated with decreased metabolic functions of the liver. The objective of this review was to give an overview of pathology of fatty liver in dairy cows.