头孢噻呋钠混悬注射液在鹅体内的药代动力学

健康四川白鹅20只，随机分为A、B两组，A组单剂量静注头孢噻呋钠无菌粉针，B组单剂量肌注头孢噻呋钠混悬注射液，均按2．2mg·kg-1。用高效液相色谱法测定血浆中的药物浓度，3p97药代动力学程序软件处理药时数据。结果显示，A组药-时数据符合二室开放模型（W-1／C^2）；主要药代动力学参数：t1／2。0．112h，tmB2．711h，CL0．234L·kg-1·h-1，V0．064L·kg，AUC9．400mg·h·L-1,B组药-时数据也符合二室开放模型（W-1／c2）；主要药代动力学参数：t1/2结果表明，头孢噻呋钠混悬注射液在鹅体内分布广泛，生物利用度高，且具有长效缓释作用.。

Pharmacokinetics of ceftiofur sodium suspended injection in geese

Twenty healthy Siehuan white geese were allocated into two groups of 10 geese each. The geese in group A were administrated of ceftiofur sodium powder injections （2.2 mg/kg） by intra venous injection. The geese in group B were intramuscularly injected with ceftiofur sodium suspen ded injection （2. 2 mg/kg）. The plasma concentration of ceftiofur sodium was determined by HPLC. Pharmacokineties parameters were calculated by 3p97 computer program. Concentration time data for group A were best described by a two-compartment open model（W= 1/C2） and main parameters were as follows： tl/2o 0. 112 h,b/2o 2. 711 h,CL 0. 234 L. kg-1 . h-1 ,V 0. 064 L . kg 1 , AUC 9. 400 mg . h . L-1data of group B were also charactered by a two-compartment open mod- el （W=I/C2） and main parameters were as followsThese results showed that ceftio- fur sodium suspended injection had a wide body distribution, a high rate of bioavailability and a long half-time in Sichuan white geese by intramuscular injection.