Exocrine Pancreatic Adenocarcinoma and Associated Extrahepatic Biliary Obstruction in a Ferret |
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| Authors: | Jeffrey L. Rhody Bruce H. Williams |
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| Affiliation: | 1. Lakeside Veterinary Center, LLC, Laurel, MD USA;2. The Veterinary Pathology Service, Joint Pathology Center, Silver Spring, MD USA;1. Department of Veterinary Clinics, University of Pisa, San Piero a Grado Pisa, Italy;2. Veterinary Clinic Roma Sud, Roma, Italy;3. CVS Centro Veterinario Specialistico, Perugia, Italy;4. Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Naples, Italy;1. Exotic Animal and Wildlife Service, The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Midlothian, UK;2. Chester Zoo, Chester, UK;3. Department of Veterinary Science Small Animal Teaching Hospital, University of Liverpool, Neston, UK;4. Veterinary Pathology, School of Veterinary Sciences, University of Bristol, Langford, UK;1. Epidemiology and Economics Unit, Department of Veterinary Services, Kabete, Kenya;2. Tropical Veterinary Services Ltd, Karatu, United Republic of Tanzania |
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| Abstract: | A 7-year-old neutered, male, fitch ferret presented for weight loss, decreased appetite, reduced bowel movements, and occasional bruxism. Physical examination confirmed weight loss of 340 g over the preceding 7 months. Abnormal clinicopathologic results included lymphopenia, monocytosis, increased alkaline phosphatase, increased alanine transferase, markedly increased total bilirubin, and hypocalcemia. Plasma glucose was normal. After a discussion of diagnostic and therapeutic options, the owner decided to humanely euthanize the patient and consented to cosmetic necropsy. Microscopic examination of submitted tissues revealed an unencapsulated, infiltrative neoplasm that effaced the pancreatic architecture and metastasized to several other organs, including the lung, liver, and jejunum. Based on the cellular morphology, presence of distinctive rosettes, immunonegativity for insulin, and widespread metastasis, the disease diagnosis was exocrine pancreatic adenocarcinoma. |
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| Keywords: | ferret metastasis pancreatic adenocarcinoma tumor |
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