| 细菌脲酶分解尿素机制及其调控 |
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| 引用本文： | 熊展博,赵圣国,王加启. 细菌脲酶分解尿素机制及其调控[J]. 中国乳业, 2021, 0(9): 3-7. DOI: 10.12377/1671-4393.21.09.02 |
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| 作者姓名： | 熊展博 赵圣国 王加启 |
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| 作者单位： | 中国农业科学院北京畜牧兽医研究所动物营养学国家重点实验室,北京 100193 |
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| 基金项目： | 中国农业科学院科技创新工程（ASTIP-IAS12）; 动物营养学国家重点实验室（2004DA125184G2108） |
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| 摘 要： | 脲酶高效催化尿素分解,快速生成大量二氧化碳和氨,限制脲酶的活性能有效调控尿素的分解过程。在畜牧业上,反刍动物瘤胃脲酶会导致过度氮排放。本文将从细菌脲酶活性中心的结构特征、尿素水解机制和抑制剂调控脲酶活性机制进行综述,为有效调控脲酶活性提供理论基础和开发新抑制剂提供思路。
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| 关 键 词： | 细菌脲酶 尿素分解 脲酶抑制剂 抑制机制 反刍动物 瘤胃 |
Mechanism and Regulation of Urea Decomposition by Bacterial Urease |
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| XIONG Zhanbo,ZHAO Shengguo,WANG Jiaqi. Mechanism and Regulation of Urea Decomposition by Bacterial Urease[J]. China Dairy, 2021, 0(9): 3-7. DOI: 10.12377/1671-4393.21.09.02 |
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| Authors: | XIONG Zhanbo ZHAO Shengguo WANG Jiaqi |
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| Affiliation: | State Key Laboratory of Animal Nutrition,Institute of Animal Sciences, Chinese Academy of Agricultural Sciences,Beijing 100193 |
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| Abstract: | Urease can efficiently catalyze urea decomposition and produce carbon dioxide and ammonia. Limiting urease activity can effectively regulate urea decomposition process.In animal husbandry,ruminant urease can lead to excessive nitrogen emission.In this paper,the structural characteristics of urease activity center in bacteria,the mechanism of urease hydrolysis and the mechanism of urease activity regulation by inhibitors were reviewed,providing theoretical basis for effective regulation of urease activity and ideas for the development of new inhibitors. |
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| Keywords: | bacterial urease urea decomposition urease inhibitors inhibition mechanism ruminant rumen |
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