| 甘露醇脱水致血尿的临床观察和实验研究 |
| |
| 引用本文： | 梁鹿章,孔禄生,李景贵,曾军华,李娜.甘露醇脱水致血尿的临床观察和实验研究[J].湛江医学院学报,1993(4). |
| |
| 作者姓名： | 梁鹿章 孔禄生 李景贵 曾军华 李娜 |
| |
| 作者单位： | 广东医学院196医院
(梁鹿章，孔禄生，李景贵，曾军华)，湛江卫生学校(李娜) |
| |
| 摘 要： | 本文观察了30例急性中～重型颅脑损伤病人用甘露醇脱水后尿液变化情况,并用家兔做动物实验。证实甘露醇脱水可致血尿,以镜下血尿为主。其产生的机理考虑为其高渗作用使肾小球基底膜通透性增加,滤过增加,红细胞漏出所致。停药后血尿可自行消失。肾脏未发现病理改变,机体无不良反应,与甘露醇肾病不同。
|
| 关 键 词： | 甘露醇 血尿 动物 实验 临床试验 兔 |
HEMATURIA INDUCED BY MANNITOL FOR DEHYDRATION : CLINICAL OBSERVATION AND EXPERIMENTAL STUDY |
| |
| Liang Luzhang Li Na Kong Lusheng Li Jinggui Zeng Junhua.HEMATURIA INDUCED BY MANNITOL FOR DEHYDRATION : CLINICAL OBSERVATION AND EXPERIMENTAL STUDY[J].Journal of Guangdong Medical College,1993(4). |
| |
| Authors: | Liang Luzhang Li Na Kong Lusheng Li Jinggui Zeng Junhua |
| |
| Institution: | Liang Luzhang Li Na Kong Lusheng Li Jinggui Zeng Junhua
(196th Hospital of PLA )(Zhanjiang Medical School) |
| |
| Abstract: | Urine changes of 30 patients suffering from acute mid or severe brain injured who were treated
with mannitol were observed,and the same experiment was carried out with rabbits. The results showed that mannitol for dehydration was able to cause hematuria,mainly appearing under microscope. Its mechanism might be that hypertonus led glomerule basic membrane to increasing permeability so that infiltration raised and red blood cells leaked. When mannitol was not used,the hematuria would disappear soon. No any pathologic changes occured in kidney
and no adverse reaction occured in boby, which was different from the mannitol nephropathy. |
| |
| Keywords: | mannitol hematuria animals laboratory clinical trials rabbits |
| 本文献已被 CNKI 等数据库收录！ |
