Chronotypology and melatonin alterations in minimal hepatic encephalopathy |
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Authors: | Dimitrios Velissaris Vasilis Karamouzos Panagiotis Polychronopoulos Menelaos Karanikolas |
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Affiliation: | (1) Department of Anaesthesiology and Critical Care Medicine, Patras University Hospital, Rion, 26500, Greece;(2) Department of Neurology, Patras University Hospital, Rion, 26500, Greece |
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Abstract: | Background "Minimal (subclinical) hepatic encephalopathy" is a term that describes impairment of every day life activities in cirrhosis patients without clinical neurologic abnormalities. Melatonin diurnal pattern disruption and metabolic changes due to liver insufficiency can affect the human biologic clock. Our study was conducted to measure plasma melatonin levels in an attempt to correlate plasma melatonin abnormalities with liver insufficiency severity, and describe chronotypology in cirrhosis patients with minimal encephalopathy. |
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