白血病抑制因子及其受体在月经周期猕猴输卵管内的表达

应用免疫细胞化学方法对白血病抑制因子(LIF)、白血病抑制因子受体(LIFR)和gp130在月经周期猕猴输卵管内的表达进行了研究。结果表明，LIF、LIFR和gp130主要在输卵管上皮细胞内表达，而在固有层、肌层及泉膜内的表达量较少。LIF、LIFR和gp130在猕猴输卵管内的表达量随月经周期的不同而变化，在增殖中期到分泌中期的输卵管内表达量较高，而在增殖早期及分泌晚期输卵管内表达量较低。LIF及其受体在猕猴输卵管内的表达可能由卵巢分泌的类固醇激素所调控，LIF可能在猕猴排卵及早期胚胎发育过程中起重要的调节作用。

Presence of Leukemia Inhibitory Factor and Its Receptors in Rhesus Monkey Oviduct During the Menstrual Cycle

This study was done to examine immunohistochemically the presence of LIF,LIFR and gp130 in the monkey oviduct during the menstrual cycle.The results showed that the oviduct epithelial cells were the primary site of immunoreactive LIF,LIFR and gp130,which were present to a lesser extent in the stromal cells,smooth muscle cell layers and serosal tissue.The immunostaining for LIF,LIFR and gp130 was cycle-dependent,and considerably higher during mid-to-late proliferative to early-to-mid secretory phases than during early proliferative and late secretory phases of the menstrual cycle.These results demonstrate that rhesus monkdy oviduct contains immunoreactive proteins for LIF,LIFR and gp130 during the menstrual cycle.The cycle dependency suggests a potential regulation of their expression by ovarian steroids.The results imply the importance of LIF in a variety of oviduct biochemical and physiological functions and possibly in early embryonic development.