| N-取代苯并口恶嗪酮类化合物的合成及其生物活性 |
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| 引用本文： | 吴郴郴,袁莉萍,曹瑾,倪长春,沈宙,张一宾. N-取代苯并口恶嗪酮类化合物的合成及其生物活性[J]. 农药学学报, 2007, 9(2) |
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| 作者姓名： | 吴郴郴 袁莉萍 曹瑾 倪长春 沈宙 张一宾 |
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| 作者单位： | 华东理工大学,药学院,上海,200237;上海市农药研究所,上海,200032 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 为寻求具有高生物活性的新农药化合物,以邻氨基苯酚为原料设计合成了N-取代的苯并口恶嗪酮类化合物18个,其化学结构经1H NMR及元素分析确证。初步的生物活性测试结果表明,部分化合物具有良好的除草活性,如化合物c3、c5、c6、c7和c8在浓度为100mg/L时对苋菜Ambrosia tricolorL inn.的抑制率达90%。
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| 关 键 词： | 苯并口恶嗪酮 合成 烃基化 生物活性 |
Synthesis and Biological Activity of N-Substituted 4H-benzoxazin-3-one |
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| WU Chen-chen,YUAN Li-ping,CAO Jin,NI Chang-chun,SHEN Zhou,ZHANG Yi-bin. Synthesis and Biological Activity of N-Substituted 4H-benzoxazin-3-one[J]. Chinese Journal of Pesticide Science, 2007, 9(2) |
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| Authors: | WU Chen-chen YUAN Li-ping CAO Jin NI Chang-chun SHEN Zhou ZHANG Yi-bin |
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| Abstract: | In search of novel compounds with high biological activities,18 N-substituted benzoxazinone derivatives were designed and synthesized.Their chemical structures were confimed by 1H NMR and elemental analysis.Preliminary bioassays showed that some of them have good herbicidal activity.The inhibition rate of c3,c5,c6,c7 and c8 to Ambrosia tricolor Linn.was up to 90% at the concentration of 100 mg/L. |
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| Keywords: | benzoxazinone synthesis hydrocarbylation bioactivity |
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