Growth suppression of HER2-overexpressing breast cancer cells by berberine via modulation of the HER2/PI3K/Akt signaling pathway |
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Authors: | Kuo Han-Peng Chuang Tzu-Chao Yeh Ming-Han Hsu Shih-Chung Way Tzong-Der Chen Po-Yuan Wang Shan-Shue Chang Yung-Hsien Kao Ming-Ching Liu Jah-Yao |
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Institution: | Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan. |
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Abstract: | Berberine (BBR) is a natural alkaloid with significant antitumor activities against many types of cancer cells. This study investigated the molecular mechanisms by which BBR suppresses the growth of HER2-overexpressing breast cancer cells. The results show that BBR induces G1-phase cell cycle arrest by interfering with the expression of cyclins D1 and E and that it induces cellular apoptosis through the induction of a mitochondria/caspase pathway. The data also indicate that BBR inhibits cellular growth and promotes apoptosis by down-regulating the HER2/PI3K/Akt signaling pathway. Furthermore, it is also shown that a combination of taxol and BBR significantly slows the growth rate of HER2-overexpressing breast cancer cells. In conclusion, this study suggests that BBR could be a useful adjuvant therapeutic agent in the treatment of HER2-overexpressing breast cancer. |
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