新型广谱驱虫药氨基苯脒类化合物对感染旋毛虫小鼠的疗效的初步观察

目的观察氨基苯脒类化合物(代号9856)对感染旋毛虫小鼠的疗效。方法将氨基苯脒类化合物9856分为3个药物剂量组10 mg/kg、20 mg/kg和30 mg/kg给感染旋毛虫的实验小鼠喂药,观察药物对小鼠体内旋毛虫的4个不同发育期的作用。结果化合物9856 3个剂量组对肠道脱囊期幼虫的减虫率均为100%;对肠道内成虫期,3组的减虫率分别为76%,91.9%和97.4%;对移行期幼虫减虫率分别为65.5%,74.8%和92.3%;对肌肉内成囊期幼虫的减虫率为53.2%,61.5%和87.8%。结论化合物9856对旋毛虫4个发育期都有显著的杀虫效果。

PRELIMINARY OBSERVATION OF THE EFFECT OF AMINOPHENYLAMIDINES COMPOUNDS,A NEW HELMINTHIC,ON TRICHINELLA SPIRALIS IN MICE

Objective To observe the effect of Aminophenylamidines Compounds (9856) on Trichinella spiralis in mice.Methods Three different dosages of the drug,10 mg/kg,20 mg/kg and 30 mg/kg were given to the infected mice.And four development stages of the worm in mice were observed after the drug treatment.Results The reduction rates of larva on the stage of excystation in intestine were 100% for the three experimental groups,and the reduction rates of worms on adult stages were 76%,91.9% and 97.4%,respectively.For the larva of migration stage in muscles,the reduction rates were 65.5%,74.8% and 92.3%,and for encystation stage were 53.2%,61.5% and 87.8%.Conclusion It indicated that Aminophenylamidines Compounds(9856) has a remarkable effect on Trichinella spiralis in all its four development stages.