Structural basis of transcription: separation of RNA from DNA by RNA polymerase II |
| |
Authors: | Westover Kenneth D Bushnell David A Kornberg Roger D |
| |
Affiliation: | Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305-5126, USA. |
| |
Abstract: | The structure of an RNA polymerase II-transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|