Antiparasitic antioxidant phenylpropanoids and iridoid glycosides from Tecoma mollis |
| |
Authors: | Abdel-Mageed Wael M Backheet Enaam Y Khalifa Azza A Ibraheim Zedan Z Ross Samir A |
| |
Affiliation: | Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt. Waelabdelmageed@yahoo.com |
| |
Abstract: | A radical scavenging guided phytochemical study on the stem bark of Tecoma mollis afforded seven active phenylpropanoid glycosides (1–7), including a new one (4), and one iridoid (8). The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Compounds (1–7) displayed promising antioxidant activity (DPPH assay) in relation to ascorbic acid (positive control). The antimicrobial activity for compounds (1–8) was evaluated against five bacterial and five fungal strains. The isolated compounds exhibited nonselective weak to moderate antimicrobial activity. The highest antileishmanial activity against Leishmania donovani was observed for compound (7) with an IC50 value of 6.71 μg/ml, using pentamidine and amphotericin B as drug controls. Compound (5) exhibited moderate antimalarial activity (45% inhibition) against chloroquine sensitive (D6) clones of Plasmodium falciparum. |
| |
Keywords: | Tecoma mollis Phenylpropanoid glycosides Iridoid Radical scavenging activity Antileishmanial activity Antimalarial activity Antimicrobial activity |
本文献已被 ScienceDirect PubMed 等数据库收录! |