USE OF [123I]-2-IODO-l-PHENYLALANINE AS A TUMOR IMAGING AGENT IN TWO DOGS WITH SYNOVIAL CELL SARCOMA |
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| Authors: | K PEREMANS V KERSEMANS T LIUTI E VANDERMEULEN B CORNELISSEN I GIELEN B DE SPIEGELEER J MERTENS C BURVENICH G SLEGERS |
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| Institution: | Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium. Kathelijne.Peremans@UGent.be |
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| Abstract: | 123I]-iodo-L-phenylalanine was successfully evaluated for gamma camera imaging in vivo in tumor-bearing athymic mice and in humans with brain tumors. Here, we report the use of this tracer in two dogs with synovial cell sarcoma of the tarsus. 123I]-iodo-L-phenylalanine was quantitatively prepared as a kit formulation using the Cu(1+) +-assisted nucleophilic exchange. Rapid 123I]-2-iodo-L-phenylalanine tumor accumulation was observed with good tumor to background contrast and rapid clearance in these two dogs. This radiopharmaceutical is a promising alternative tumor tracer to overcome the known limitations of 18F-fluorodeoxyglucose and, when labelled with radioiodine-131, has the potential to be used for therapeutic purposes. |
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| Keywords: | [123I]-2-iodo-l-phenylalanine dogs gamma camera imaging synovial carcinoma tumor diagnosticum |
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