Chirality: a major issue in veterinary pharmacology |
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Authors: | M. F. LANDONI,P. LEES&dagger |
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Affiliation: | Catedra de Farmacologia, Facultad de Ciencias Veterinarias, Universidad National de La Plata, La Plata, Argentina;Department of Veterinary Basic Sciences, The Royal Veterinary Collage, Hatfield, Herts, UK |
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Abstract: | The sole purpose of this comment is to draw attention to the significance of enantiomorphism in the interpretation of pharmacokinetic/pharmacodynamic studies of drugs that are present in dosage forms as racemates. The proportion of the enantiomers formed from a racemate can vary in different animal species, and both the pharmacokinetic behaviour and pharmacodynamic activity can differ between the enantiomers. As a consequence, the pharmacological effects produced by a racemic drug represent the combined effects of the enantiomers formed in the particular species of animal. Enantiomorphism has a major influence on the prediction of dosage regimens for different animal species. |
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