Two antimycin A analogues from marine-derived actinomycete Streptomyces lusitanus |
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| Authors: | Han Zhuang Xu Ying McConnell Oliver Liu Lingli Li Yongxin Qi Shuhua Huang Xiangzhong Qian Peiyuan |
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| Institution: | Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. zhuanghan@ust.hk |
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| Abstract: | Two new antimycin A analogues, antimycin B1 and B2 (1-2), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 μg/mL, respectively. |
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| Keywords: | marine-derived actinomycete Streptomyces lusitanus antibacterial antimycin B |
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