Novel stilbenoids isolated from the heartwood of <Emphasis Type="Italic">Shorea laeviforia</Emphasis> |
| |
Authors: | Y Hiramo R Kondo K Sakai |
| |
Institution: | (1) Interior Design Research Institute, Fukuoka Industrial Technology Center, 405-3 Agemaki, Okawa, Fukuoka 831-0031, Japan Tel. +81-944-86-3259; Fax +81-944-86-4744 e-mail: hirano@fitc.pref.fukuoka.jp, JP;(2) Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan, JP |
| |
Abstract: | Two novel stilbenoids, laevifonol (an ε-viniferin-ascorbic acid hybrid compound) and laevifoside (an O-glucoside of ampelopsin A) were isolated from the heartwood of Shorea laeviforia. Their structures were elucidated by nuclear magnetic resonance spectroscopic evidence including HMQC, HMBC, and NOESY. The
novel compounds and other known stilbenoids from S. laeviforia were evaluated for inhibitory activity against rat liver 5α-reductase. Positive inhibitory activities were observed in resveratrol dimers and tetramers. No inhibitory activity was detected
in laevifonol and ampelopsin A glucosides, laevifoside, or hemsleyanoside, whereas inhibitory activity was seen in their aglycon.
These results suggest that the hydrophilic moiety in these compounds may inhibit action with the hydrophobic active site of
the enzyme.
Received: November 21, 2001 / Accepted: February 8, 2002
Acknowledgment We are grateful to Dr. Wasrin Syafii (Bogor Agricultural University, Indonesia) for the collection of plant material.
Correspondence to:Y. Hiramo |
| |
Keywords: | Shorea laeviforia ε -Viniferin– ascorbic acid hybrid Ampelopsin A O-glucoside Oligostilbenes Rat liver 5α -reductase inhibitor |
本文献已被 SpringerLink 等数据库收录! |
|