Response of Canine Mast Cell Tumors to Treatment With Oral Prednisone |
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| Authors: | Dudley L McCaw Margaret A Miller Gregory K Ogilvie Stephen J Withrow William G Brewer Jr Mary Kay Klein Ford W Bell Sharon K Anderson |
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| Institution: | Veterinary Cooperative Oncology Group, Contributing institutions were: University of Missouri, Tucson, AZ;Colorado Stale University, Tucson, AZ;Auburn University, Tucson, AZ;Oncology Referral Center, Tucson, AZ;University of Minnesota, Tucson, AZ |
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| Abstract: | Twenty-five dogs with naturally occurring mast cell tumors were treated with daily oral prednisone (1 mg/kg) for 28 days. Five dogs (20%) had reduction in tumor volume and were considered responders. Four of these underwent partial remission and one underwent complete remission. Survival times for the five responders were 3, 5, 6, 7.5, and greater than 28 months, respectively. We therefore conclude that prednisone is effective in some canine mast cell tumors. Further studies are indicated to determine the most effective dose of prednisone, the appropriate duration of treatment, and the efficacy in more benign mast cell tumors, and in combination with other forms of therapy. |
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