Acylated flavonol glycoside from Platanus orientalis |
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| Authors: | Tantry Mudasir A Akbar Seema Dar Javid A Irtiza Syed Galal Ahmed Khuroo Mohammad A Ghazanfar Khalid |
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| Institution: | National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, MS 38677, United States. mtantry@olemiss.edu |
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| Abstract: | The ethylacetate and n-butanol fractions of ethanolic extract of Platanus orientalis leaves led to the isolation of new acylated flavonol glycoside as 3',5,7-trihydroxy-4'-methoxyflavonol 3-O-2-O-(2,4-Dihydroxy)-E-cinnamoyl-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl (1→2)]-β-D-glucopyranoside, along with seven known compounds. All the compounds were characterized by NMR including 2D NMR techniques. The isolates were evaluated for NF-κB, nitric oxide (NO), aromatase and QR2 chemoprevention activities and some of them appeared to be modestly active. |
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| Keywords: | Platanus orientalis Acylated flavonol glycosides Platanoside M NF-κB NO Aromatase |
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