Vaccination of cyclophosphamide-treated chickens against Newcastle disease virus infection |
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Authors: | K M Lam Q Hao |
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Institution: | Department of Epidemiology and Preventive Medicine, School of Veterinary Medicine, University of California, Davis 95616. |
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Abstract: | Newly-hatched chickens were treated with 3 mg of cyclophosphamide (CY) per day for 4 consecutive days. At 2 weeks of age, these chickens, together with a group of untreated controls, were vaccinated intranasally or subcutaneously with the La Sota strain of Newcastle disease virus (NDV). All chickens were challenged intranasally with the GB strain of NDV 2 weeks later. CY-treated, intranasally vaccinated chickens were highly resistant to NDV challenge, yet none of the chickens produced any detectable humoral antibodies to NDV; antibodies to NDV were detectable in the tracheal washings, however. |
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