| 复方刺五加注射液对大鼠实验性心肌缺血的保护作用 |
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| 引用本文： | 肖芳,于小风,曲绍春,徐华丽,睢大员. 复方刺五加注射液对大鼠实验性心肌缺血的保护作用[J]. 人参研究, 2007, 19(1): 2-4 |
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| 作者姓名： | 肖芳 于小风 曲绍春 徐华丽 睢大员 |
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| 作者单位： | 吉林大学药学院药理教研室·长春·130021;吉林大学药学院药理教研室·长春·130021;吉林大学药学院药理教研室·长春·130021;吉林大学药学院药理教研室·长春·130021;吉林大学药学院药理教研室·长春·130021 |
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| 摘 要： | 通过异丙肾上腺素及垂体后叶素诱发大鼠急性心肌缺血模型,观察复方刺五加注射液对实验性心肌缺血的保护作用。结果表明,复方刺五加注射液25、50、100mg/kg对皮下注射异丙肾上腺素缩短小鼠在常压缺氧状态下的存活时间均具有明显对抗作用;复方刺五加注射液20、40、80mg/kg可明显减轻静脉注射垂体后叶素诱发的大鼠急性心肌缺血心电图(ST段抬高及T波高耸)变化程度,表明复方刺五加注射液对大鼠实验性心肌缺血具有明显保护作用。
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| 关 键 词： | 复方刺五加注射液 心肌缺血 异丙肾上腺素 垂体后叶素 |
Protective Effect of CAI on Experimental Myocardial Ischemia |
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| Xiao Fang,Yu Xiao-feng,Qu Shao-chun,Xu Hu-ali,Sui Da-yuan. Protective Effect of CAI on Experimental Myocardial Ischemia[J]. Ginseng Research, 2007, 19(1): 2-4 |
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| Authors: | Xiao Fang Yu Xiao-feng Qu Shao-chun Xu Hu-ali Sui Da-yuan |
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| Affiliation: | Department of Pharmacology, Pharmacy College, JiLin University ,ChangChun 130021 |
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| Abstract: | Protective effect of Compound Acanthopanax senticosus Injection(CAI)on experimental myocardial ischemia was observed with acute myocardial ischemiamodel induced by isoprenaline(Isop.) in mice and posterior-pituitary(Pit) in rats.Theresults showed that CAI(25,50 and 100mg/kg,ip) could prolong significantlysurvival time in normal pressure anoxia induced by Isop.and CAI(20,40 and80mg/kg,ip) could decrease degrees of myocardial ischemia ECG induced by Pit.It isindicated that CAI has the significant protective effect on myocardial ischemia. |
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| Keywords: | CAI Myocardial ischemia Isoprenaline Posterior-pituitary ECG |
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