| 中间球海胆体腔液提取物对HEPG_2细胞的脂质过氧化作用 |
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| 引用本文： | 葛姗姗,李霞,秦艳杰. 中间球海胆体腔液提取物对HEPG_2细胞的脂质过氧化作用[J]. 大连水产学院学报, 2010, 25(5): 456-459 |
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| 作者姓名： | 葛姗姗 李霞 秦艳杰 |
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| 作者单位： | 大连海洋大学,农业部海洋水产增养殖学重点开放实验室,辽宁,大连,116023 |
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| 基金项目： | 国家自然科学基金资助项目(30800849) |
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| 摘 要： | 研究了不同浓度中间球海胆Strongylocentrotus intermedius体腔液提取物对人肝癌细胞HEPG2的超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）活性及丙二醛（MDA）含量的影响。结果显示：用中间球海胆体腔液提取物处理HEPG2细胞24 h后,SOD、CAT、GSH-Px的活性随加入提取物浓度的增加而降低,MDA含量随加入提取物浓度的增加而增加,呈现剂量依赖关系。说明中间球海胆体腔液提取物破坏了HEPG2细胞抗氧化系统的动态平衡,可引起人肝癌细胞HEPG2脂质过氧化损伤。
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| 关 键 词： | 中间球海胆 人肝癌细胞HEPG2 超氧化物歧化酶 过氧化氢酶 谷胱甘肽过氧化物酶 丙二醛 |
The effect of the extraction from coelomic fluid in sea urchin Strongylocentrotus intermedius on lipid peroxidation in HEPG_2 cells in human |
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| GE Shan-shan,LI Xia,QIN Yan-jie. The effect of the extraction from coelomic fluid in sea urchin Strongylocentrotus intermedius on lipid peroxidation in HEPG_2 cells in human[J]. Journal of Dalian Fisheries University, 2010, 25(5): 456-459 |
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| Authors: | GE Shan-shan LI Xia QIN Yan-jie |
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| Affiliation: | GE Shan-shan,LI Xia,QIN Yan-jie(Key Laboratory of Mariculture,Agriculture Ministry,PRC,Dalian Ocean University,Dalian 116023,China) |
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| Abstract: | The effects of different concentrations of extracts from coelomic fluid in sea urchin Strongylocentrotus intermedius on the cellular superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GPH-Px) activities and malonaldehyde(MDA) content were studied in HEPG2 cells in human.There were increase in the activities of SOD,CAT,GSH-Px in the human HEPG2 cells treated by the extract for 24 h.The MDA content were found to increase with increasing dose of the extract,indicating that the extract from coelomic... |
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| Keywords: | Strongylocentrotus intermedius HEPG2 cell superoxide dismutase catalase glutathione peroxidase malonaldehyde |
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