蕨麻多糖对小鼠免疫功能的影响

用环磷酰胺作为免疫抑制剂小鼠腹腔注射(100mg/kg)建立免疫抑制模型,观察不同剂量蕨麻多糖(50、100、200、400mg/kg)对小鼠脾脏指数、胸腺指数及血清溶菌酶活力的影响.结果显示,蕨麻多糖能明显提高正常小鼠脾脏指数、胸腺指数及免疫抑制小鼠脾脏指数;增强正常小鼠和免疫抑制小鼠血清溶菌酶活力,尤其在免疫抑制状态下,增强作用更明显.表明该多糖可对抗Cy所致的免疫抑制,明显地增强小鼠免疫功能.

Effects of Potentilla anserine polysaccharide on immune functions in mice

The study was carried out to investigate thymus index, splenic index and the level of serum activity of lysozyme in mice treated with cyclophosphamide (Cy)(100mg/kg) in vivo by intraperitoneal injection at different Potentilla anserine polysaccharide (PAP) doses of 50 mg/kg,100 mg/kg ,200 mg/kg or 400 mg/kg. The result showed that intraperitoneal administration of the polysaccharide could siginificantly raise the thymus and spleen indices and increase the serum activity of lysozyme in a dose-dependent manner. In conclusion, Potentilla anserine polysaccharide was able to overcome cyclophosphamide-induced immunosuppression, and had markedly immunomodulation functions.