Thiamylal-Sparing Effect of Midazolam for Canine Endotracheal Intubation A Clinical Study of 118 Dogs |
| |
| Authors: | STEPHEN A GREENE dvm MS Diplomate acva G JOHN BENSON dvm MS Diplomate ACVA SANDEE M HARTSFIELD dvm ms Diplomate acva |
| |
| Institution: | Department of Veterinary Clinical Medicine and Surgery, Washington State University, Pullman, Washington (Greene), the Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Ilinois (Benson);Department of Small Animal Medicine and Surgery, Texas Veterinary Medical Center, Texas A&M University, College Station, Texas (Hartsfield). |
| |
| Abstract: | One hundred eighteen dogs were studied at three veterinary teaching hospitals after the administration of midazolam (0.1 mg/kg, intravenously IV]) or a placebo. Midazolam and placebo treatments were randomized and blinded to the investigators. The dose of thiamylal required for tracheal intubation 3 to 5 minutes after midazolam or placebo was calculated. The dose of thiamylal at the three hospitals was 10.6,9.8, and 10.1 mg/kg IV after midazolam, and 12.1,11.2, and 11.6 mg/kg IV after placebo. Pooled data from the three hospitals yielded a significant (p < .001) decrease in mean IV thiamylal dose after midazolam (10.2 mg/kg) compared with placebo (11.6 mg/kg). Overall, there was a 12% decrease in the dose of thiamylal required for tracheal intubation after midazolam compared to that after the placebo. The thiamylal dose was significantly (p < .001) decreased after midazolam compared with placebo for dogs weighing more than 15 kg but not for dogs weighing less than 15 kg. |
| |
| Keywords: | |
|
|
